Virtual ADMET Assessment in Target Selection and Maturation

Virtual ADMET Assessment in Target Selection and Maturation

"Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods have accelerated the process towards drugability of new chemical structures. Another component of the revolution in drug discovery is the replacement of the disease (indication)-based approach by a target-based approach. A better understanding of pathophysiology of diseases and the underlying biological processes of diseases combined with explosive development of genomics and proteomics have been instrumental in the birth of this new paradigm. This volume summarizes discussions of these three aspects of modern drug discovery, i.e. priority for targets, early ADMET assessment, and in silico screening. We trust that readers from academia as well as from industry will benefit from these studies."


Author
Publisher IOS Press
Release Date
ISBN 158603703X
Pages 268 pages
Rating 4/5 (31 users)

More Books:

Virtual ADMET Assessment in Target Selection and Maturation
Language: en
Pages: 268
Authors: Bernard Testa
Categories: Medical
Type: BOOK - Published: 2006 - Publisher: IOS Press

"Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacok
In Silico Toxicology
Language: en
Pages: 689
Authors: Mark T. D. Cronin
Categories: Medical
Type: BOOK - Published: 2010 - Publisher: Royal Society of Chemistry

In silico methods to predict toxicity are becoming increasingly important, particularly in light of European legislation such as Reach and the Cosmetics Regulat
Drug Bioavailability
Language: en
Pages: 649
Authors: Han van de Waterbeemd
Categories: Medical
Type: BOOK - Published: 2009-09-18 - Publisher: John Wiley & Sons

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritt
Human Papillomaviruses and Cervical Cancer
Language: en
Pages: 164
Authors: Magnus von Knebel Doeberitz
Categories: Medical
Type: BOOK - Published: 2007 - Publisher: IOS Press

Contains twelve articles which explore the epidemiology of HPV, testing strategies for HPV infections, new HPV detection methods and other potential biomarkers
Epigenetic Markers
Language: en
Pages: 148
Authors: M. Widschwendter
Categories: Medical
Type: BOOK - Published: 2007 - Publisher: IOS Press

DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA's four bases, cytosine. These changes are responsible for controlli
Pulmonary Arterial Hypertension
Language: en
Pages: 116
Authors: Jochen Antel
Categories: Medical
Type: BOOK - Published: 2010 - Publisher: IOS Press

Pulmonary hypertension is a fatal lung and heart disease. It is characterized by shortness of breath, fatigue and fainting. It is exacerbated by an increase of
Towards Drugs of the Future
Language: en
Pages: 141
Authors: Chris G. Kruse
Categories: Medical
Type: BOOK - Published: 2008 - Publisher: IOS Press

The Meaning of Dwelling Features. Conceptual and Methodological Issues relates the research areas of housing preferences and the meaning of a dwelling with each
Cardiovascular Benefits of Omega-3 Polyunsaturated Fatty Acids
Language: en
Pages: 196
Authors: B. Maisch
Categories: Medical
Type: BOOK - Published: 2007-01-18 - Publisher: IOS Press

During the last decades progress has been made in the treatment of patients who survived myocardial infarction. Nevertheless, patients who survive an acute myoc
Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases
Language: en
Pages: 129
Authors: Jean-Louis Junien
Categories: Medical
Type: BOOK - Published: 2008 - Publisher: IOS Press

Focuses on the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological disorders. This book also focuses on possible explanati
In-Silico Lead Discovery
Language: en
Pages: 201
Authors: Maria A. Miteva
Categories: Science
Type: BOOK - Published: 2011 - Publisher: Bentham Science Publishers

Computer-aided drug design and in silico screening have contributed to the discovery of several compounds that have either reached the market or entered clinica